Advances in Immunotherapy for Glioblastoma Multiforme

نویسندگان

  • Boyuan Huang
  • Hongbo Zhang
  • Lijuan Gu
  • Bainxin Ye
  • Zhihong Jian
  • Creed Stary
  • Xiaoxing Xiong
چکیده

Glioblastoma multiforme (GBM) is the most common primary malignant brain tumor in adults. Patients with GBM have poor outcomes, even with the current gold-standard first-line treatment: maximal safe resection combined with radiotherapy and temozolomide chemotherapy. Accumulating evidence suggests that advances in antigen-specific cancer vaccines and immune checkpoint blockade in other advanced tumors may provide an appealing promise for immunotherapy in glioma. The future of therapy for GBM will likely incorporate a combinatorial, personalized approach, including current conventional treatments, active immunotherapeutics, plus agents targeting immunosuppressive checkpoints.

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عنوان ژورنال:

دوره 2017  شماره 

صفحات  -

تاریخ انتشار 2017